Between approximately 50,000 and 30,000 years ago, interbreeding occurred between Denisovans and ancestors of modern humans in Southeast Asia and Oceania. Genetic studies show present-day Melanesians, Aboriginal Australians, and some Filipino populations carry up to 6% Denisovan DNA. Evidence suggests at least two distinct Denisovan lineages contributed to the modern human genome through multiple interbreeding events. Denisovan genes contribute to high-altitude adaptation in Tibetans and immune system functions in Papuans. Denisovan genetic material spans from Siberia to Southeast Asia and Oceania.