The formation of the first atomic nuclei in the universe through nuclear fusion reactions occurring 20 minutes to 3 minutes after the Big Bang. As the universe cooled below 10 billion Kelvin, protons and neutrons combined to form light elements including approximately 75% hydrogen, 25% helium-4, and trace amounts of deuterium and lithium. This process ended when the temperature and density became too low for significant fusion to occur, establishing the primordial abundance of light elements that remains largely unchanged today.