The Indian Removal Act was passed by Congress on May 28, 1830, and signed into law by President Andrew Jackson. The Act authorized the President to negotiate with Native American tribes in the southeastern United States for their removal to federal territory west of the Mississippi River in exchange for their ancestral homelands. This legislation led to the forced relocation of approximately 60,000 Native Americans, including the Cherokee, Creek, Chickasaw, Choctaw, and Seminole tribes, in what became known as the Trail of Tears, during which thousands died.