Around 4000 BCE, Uruk in southern Mesopotamia emerged as one of the earliest major urban centers. The settlement developed from merging two smaller Ubaid communities - the Eanna and Anu districts, each centered around temple complexes. Uruk developed monumental mud-brick architecture, specialized labor, administrative systems, and early proto-writing forms. Its population reached an estimated 40,000 residents with thousands more in surrounding areas. The city marked a shift from small agricultural villages to complex urban societies with stratified social structures and concentrated economic power.