Bolivar's unified republic of Gran Colombia fractures along regional lines as Venezuela secedes under Jose Antonio Paez, Ecuador declares independence on May 13 under Juan Jose Flores, and the remaining territory reorganizes as the Republic of New Granada. Bolivar resigns the presidency on May 4 and dies on December 17 in Santa Marta. The dissolution stems from tensions between federalists and centralists, vast geographic distances, weak inter-regional economic ties, and competing caudillo power bases.